pheochromocytoma benign tumor of the adrenal glands, it is by its very nature is often a benign tumor, only in rare cases (10%), it can acquire the features of a malignant tumor.The adrenal glands - a ductless glands that synthesize and secrete into the blood to the body's most important hormones.They are located above the upper pole of the kidney.
in the adrenal medulla synthesize hormones:
When developing pheochromocytoma - excessive growth of the tissue in the form of benign tumor is increased and production of these hormones.Cells similar medullary layer of the adrenal glands, is also in sympathetic ganglia, located in the neck, mediastinum, pericardium, abdomen and pelvic cavity.There may also develop benign tumors actively producing adrenal hormones.
hormones adrenal medulla called catecholamines.Increased production of catecholamines leads to an increase in blood pressure.In most cases, the disease is in the form of periodic abrupt rise in blo
Stroke When there is a sharp rise in blood pressure, especially diastolic.May include the values in the region of 200-300 / 140-200 mm HgAgainst this background, there are headaches, sometimes - pain in the heart, abdomen, back pain, nausea, vomiting.Increased body temperature.There is a feeling of thirst and frequent urination.At the same person may experience severe anxiety, fear.There profuse sweating, heart palpitations, shortness of breath, fever, pale skin, or, on the contrary, it develops redness, pupils contracted.The ECG can be detected cardiac arrhythmia.
crisis continues from several minutes to several hours, then it feels better.By the end of crisis often occur frequent urination, sweating, and some euphoria.
If you develop severe conditions like heart failure, pulmonary edema, heart attack, stroke, crisis can also lead to death.In some cases the crisis occurs without a significant increase in blood pressure in the presence of other signs of overproduction of catecholamines.Less pheochromocytoma proceeds not in the form of crises, and a persistent increase in blood pressure.To complement the characteristic clinical picture of the disease is determined by the amount of catecholamines and their metabolites in blood and urine.
benign tumor of the adrenal glands can be detected by computed tomography, scintigraphy.Aortography reveals extraadrenal tumor localization.Pheochromocytoma can only be removed surgically.Before surgery, blood pressure was reduced to normal values using alpha-blockers long-acting (phenoxybenzamine or prazosin).Also, long-term treatment using drugs that inhibit the formation of catecholamines - alpha metilparatirozin.Treatment of crises consists in intravenous administration of alpha-adrenergic blockers: phentolamine, thropaphen, prazosin, sodium nitroprusside.